O-31: AMH and AMHR2 Genetic Variants in Chinese Women with Primary Ovarian Insufficiency and Normal Age at Natural Menopause

Interactions between Genetic Variants in AMH and AMHR2 May Modify Age at Natural Menopause

The onset of menopause has important implications on women's fertility and health. We previously identified genetic variants in genes involved in initial follicle recruitment as potential modifiers of age at natural menopause. The objective of this study was to extend our previous study, by searching for pairwise interactions between tagging single nucleotide polymorphisms (tSNPs) in the 5 gene...

Age at Menopause and Its Main Predictors among Iranian Women

Determinants of Age at Natural Menopause in Shiraz

The mean age at natural menopause and its determinants among Shirazi women (southern Iran) was calculated.  The data were obtained from a population- based cross-sectional study carried out in the year 2000.  Interviews were carried out and observations made on 948 women who had incurred natural menopause. They were randomly chosen using postal zones housing sample framework of Shiraz.Mean±SD a...

Notice of Retraction: Association study of TGFBR2 and miR-518 gene polymorphisms with age at natural menopause, premature ovarian failure and early menopause among Chinese Han women

Age at natural menopause (ANM), a highly heritable phenotype, has been identified to be closely associated with major hormone-related diseases, including breast cancer and gynecological cancers. We previously identified an important role for the transforming growth factor, β receptor II (TGFBR2) gene polymorphisms in breast cancer susceptibility among Asian women. Considering the important role...

Association Study of TGFBR2 and miR-518 Gene Polymorphisms With Age at Natural Menopause, Premature Ovarian Failure, and Early Menopause Among Chinese Han Women: Retracted

Age at natural menopause (ANM), a highly heritable phenotype, has been identified to be closely associated with major hormone-related diseases, including breast cancer and gynecological cancers. We previously identified an important role for the transforming growth factor, β receptor II (TGFBR2) gene polymorphisms in breast cancer susceptibility among Asian women. Considering the important role...

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample

OBJECTIVE Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS Using data from the Nurses' Health Study (7,143 women), we validated the ANM weighted genetic risk sc...